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Antimicrobial Susceptibility of Porcine Pasteurella multocida, Streptococcus suis and Actinobacillus pleuropneumoniae

06 March 2013

Over the years 2001 to 2010 for the US and Canada, researchers found that A.pleuropneumoniae and P.multocida remained susceptible to ceftiofur, enrofloxacin, florfenicol, tilmicosin and tulathromycin while S.suis remained susceptible to ceftiofur, enrofloxacin and florfenicol.

In the latest issue of Journal of Swine Health and Production, Ellen Portis of Pfizer Animal Health (now Zoetis) and colleagues there and at Waterwood Consulting, both in Kalamazoo, Michigan, US, report their study, which aimed to provide data on the in-vitro antimicrobial susceptibility of three bacterial respiratory disease pathogens isolated from swine across the United States and Canada over the period 2001 to 2010.

A total of 1,097 Actinobacillus pleuropneumoniae, 2,389 Pasteurella multocida and 2,617 Streptococcus suis isolates recovered from diseased or dead swine from North America over a 10-year period were tested for in-vitro susceptibility to antimicrobial agents approved for treatment of swine respiratory disease. Clinical and Laboratory Standards Institute standardized methods were used to determine the minimum inhibitory concentrations (MICs) of ceftiofur, enrofloxacin, florfenicol, penicillin, tetracycline, tilmicosin and tulathromycin.

Over the years 2001 to 2010, A.pleuropneumoniae and P.multocida remained susceptible to ceftiofur, enrofloxacin, florfenicol, tilmicosin and tulathromycin, and S.suis remained susceptible to ceftiofur, enrofloxacin and florfenicol. Low penicillin MIC values for P.multocida and S.suis and higher MIC values for A.pleuropneumoniae were also seen. Most isolates of all three organisms were resistant to tetracycline over the 10 years of the survey.

Monitoring antimicrobial susceptibility among swine pathogens over time provides valuable information about changes which may be occurring in the antimicrobial susceptibility of these organisms and is an important tool in effective antimicrobial therapy, according to Portis and co-authors. Surveillance of the in-vitro susceptibility of these swine respiratory disease pathogens continues to be an important component in antimicrobial stewardship.

Reference

Portis E., Lindeman C., Johansen L. and G. Stoltman 2013. Antimicrobial susceptibility of porcine Pasteurella multocida, Streptococcus suis and Actinobacillus pleuropneumoniae from the United States and Canada, 2001 to 2010. J Swine Health Prod. 21(1):30–41.

March 2013

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