Impact of Ceftiofur on Resistant Enteric Bacteria in Finishing Pigs17 April 2013
The spread of ceftiofur-resistant bacteria in finisher pigs cannot be fully explained by simply measuring antibiotic use, according to Tom Wittum of Ohio State University in a report for the US National Pork Board.
The antibiotics, Exceed and Excenel, are two formulations of the cephalosporin drug, ceftiofur, that are commonly used to treat finishing pigs in the US. The object of this work was to understand the relationship between the use of ceftiofur and the spread of important cephalosporin resistance genes in swine finishing barns.
To accomplish this, the researchers collected approximately 30 faecal samples from each of 50 finishing barns located in five US states. They tested the samples for the presence of Escherichia coli or Salmonella that were resistant to ceftiofur and other important antibiotics. Any isolates resistant to ceftiofur were then tested for specific genes that provide resistance to important cephalosporins known as blaCTX-M and blaCMY.
Of the 1,495 total faecal samples that were tested, 109 (7.3 per cent) from 25 barns were positive for Salmonella but only two of those carried the blaCMY gene and were resistant to ceftiofur.
A total of 1,174 (78.5 per cent) of the faecal samples contained E.coli with the blaCMY gene but only 24 (1.6 per cent) contained E.coli or other bacteria with the blaCTX-M gene.
Pigs were commonly treated with ceftiofur as pigs in 41 (82 per cent) of the barns had been exposed to ceftiofur prior to finishing in either farrowing or nursery barns. In addition, individual sick pigs in 24 (48 per cent) finishing barns received ceftiofur for treatment. However, this reported ceftiofur use was not associated with the presence of E.coli carrying blaCTX-M or blaCMY.
This result suggests that the spread of resistant bacteria in swine finishing barns cannot be fully explained by simply measuring antibiotic use. Attempts to reduce resistance will likely require that complex relationships of factors be identified that promote the spread of resistant organisms and resistance genes.