Myelin Matters to Piglet Movement, Reflexes and Coordination

Agricultural Research Service (ARS) scientists have been investigating the development of the piglet's nervous system and other organs, reports Sandra Avant, ARS Information Staff. They have found that feeding sows a supplement of creatine may reduce the mortality of piglets of below-average birthweight.
calendar icon 12 February 2014
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When piglets are born, they need a certain set of skills to be able to thrive. Good coordination and quick reflexes help piglets avoid being accidentally crushed by their mother, which is a primary cause of piglet pre-weaning mortality.

As the number of piglets born in a litter increases, producers have seen a reduction in piglet birthweight and a rise in the death rate. An estimated five to 10 per cent of piglets are stillborn, and another 10 to 20 per cent do not survive to weaning.

The key to solving some of these inefficiencies in swine production may lie within the piglet’s brain.


Creatine plays a significant role in energy metabolism that has been shown to have an effect on the survival of newborn piglets until they are weaned

At the Agricultural Research Service’s Roman L. Hruska US Meat Animal Research Center in Clay Center, Nebraska, scientists have shown that in low-birthweight piglets, the brain is closer to normal size than other vital organs, suggesting its importance in survival. They are now investigating other aspects of brain development that may also affect survival.

A team led by Jeffrey Vallet, physiologist and research leader of the centre’s Reproduction Research Unit, is looking at the production of myelin - an insulating layer that forms around the nerves and is essential for proper functioning of the nervous system. In addition, the group, which includes physiologists, Jeremy Miles and Lea Rempel, is examining supplements like creatine to determine the effects on stillbirth, pre-weaning survival, and myelin production.


At Clay Center, Nebraska, physiologists Jeff Vallet and Lea Rempel examine a piglet. Their work includes looking at supplements like creatine to determine the effects on piglet stillbirth, pre-weaning survival, and myelin production.

Coordination and Reflexes Count

Myelin has broad effects on the coordination of movement and the speed of reflexes, which allows animals to move quickly and easily. Therefore, production of myelin - 'myelination' - might affect the piglets’ ability to stay alive.

“For example, when humans are born, their brains are not very well myelinated,” Dr Vallet said. “Babies can’t control their arms and legs at first but movements and other responses become steadier as they grow older.”

On the other hand, when piglets are born, most of their myelin production has already taken place, he added. “Newborn piglets need to be able to get up, move, and do everything they can to stay away from dangerous situations in their environment, or they’re not going to survive very long.”

A previous study showed that the brains of low-birthweight piglets were under-myelinated, Dr Vallet said. However, this work was not specific to myelin. It measured cholesterol - a major component of myelin but also a component of other parts of the brain.

Dr Vallet and colleagues measured proteins and phospholipids that are basic components of myelin. They compared myelin content from three specific regions - the cerebellum, brain stem and spinal cord - between the largest and smallest pig fetuses during the sow’s late pregnancy. The cerebellum controls coordination, while the brain stem and spinal cord are involved in reflexes.

Scientists found no differences between the groups in spinal cord myelination, which might be due to the fact that the spinal cord myelinates first, Dr Vallet said. “It seems likely there are mechanisms present in the spinal cord that maintain myelin in that tissue.”

The most significant difference was discovered in the brain stem, where myelination was less in the smaller pig foetuses. An examination of the cerebellum showed similar results. Together, these findings suggest that reduced myelin may contribute to poor survival of low-birthweight piglets.

“There are a lot of reasons why low-birthweight pigs don’t do very well,” Dr Vallet said. “This might be one factor we can improve on if we could figure out a way to reduce myelin deficiency.”


Piglets need to be able to move quickly to avoid dangerous situations in their environment. Myelin formation affects the coordination of movement and speed of reflexes that allow animals to move quickly and easily.

A Dose of Creatine

Other research has shown that certain essential fats must come from the diet and that myelin’s proteins interact with zinc as part of myelin formation. This suggested that essential fats or zinc might improve myelination. In a subsequent study, funded by the National Pork Board, Dr Vallet added omega-3 fatty acids and zinc to the diets of pigs but he found that neither supplement had an effect on myelination.

Scientists then looked at creatine, a compound found in muscle tissue. Creatine plays a significant role in energy metabolism, which has been shown to have a major effect on the survival of newborn piglets until they’re weaned. Creatine is involved in maintaining energy supplies for muscle contraction and is used to improve the performance of human athletes during strenuous, highly repetitive activities.

“Studies show that the birth process, stillbirth and pre-weaning mortality are related but few strategies or treatments are available to reduce delays in the birth process,” Dr Vallet said. “We thought that creatine might affect both the birth process of the sow and energy metabolism in the piglet as well as myelination.”

Pigs received either 20g of creatine or no treatment from day 110 of pregnancy until they gave birth. Video cameras were used to monitor the birth process - recording the amount of time between the births of piglets, the number of stillbirths and pre-weaning mortality. A sub-set of piglets was measured for changes in brain myelination to determine whether creatine intake by the mother altered myelination in her piglets.

“Although the birth process was not affected by creatine, the number of low-birthweight piglets crushed by their mother was reduced,” Dr Vallet said. “Also, the amounts of several phospholipids in myelin were increased by creatine treatment, particularly in the brain stem, suggesting that improved myelination may contribute to the ability of the piglet to avoid the sow when necessary.”

Further Reading

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February 2014

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