INACTIVATED PRRS VACCINE FOR SOWS AND GILTS
Clinical signs indicating that PRRS may be present in your herd
||1ST INFECTION OR OUTBREAK
||ENDEMIC PRRS INFECTION
¤ anorexia (lack of appetite) in
10 ? 15% of sows
¤ fever (>39,5?)
¤ late abortions (1 ? 6%)
¤ "blue ears" (1 ? 2%)
¤ >10% early farrowing increase in
return to service
¤ >5% early farrowings
¤ increase of 2 - 3% in rate of
¤ decrease in farrowing rate
¤ anorexia & agalactia (lack of
¤ drinking problems
¤ mummified foetuses
¤ (10 ? 15% per litter)
¤ stillbirths (30% per litter)
¤ weak piglets
¤ decrease in number of live piglets
¤ anorexia & agalactia
¤ increase in numbers of stillbirths
& mummified foetuses
¤ increase in numbers of weak
piglets and splay-legs
Post-weaning & finishing pigs >>>>>>>
¤ possible recrudescence of
¤ secondary infections (coughing,
¤ Swine influenza
¤ Aujeszky?s disease
¤ Aujeszky?s disease
¤ chronic classic swine fever
¤ bacterial cystitis/pyelonephritis
PROGRESSIS, the advantages clearly demonstrated on the farm
Controlled study on 17 PRRS contaminated farms in France. On each farm, 5 batches of
sows were vaccinated with PROGRESSIS and 2 batches were kept as unvaccinated controls.
There was a good homgenous and lasting seroconversion following vaccination. This
indicates a more even and durable immunity to PRRS in vaccinated animals. (fig. 1)
A comparison of the average GTTT* results for the vaccinated and the control sows shows
a decrease of 59% in the number of early farrowings. The magnitude of the beneficial
effects of vaccination increases in proportion to the number of booster injections. (fig. 2)
*GTTT = French national herd recording scheme
Vaccination resulted in an increase in the numbers of piglets weaned per sow per year.
It was also shown that the effects were greater in herds where seroconversion to PRRS
occurs earlier in the fattening period. (fig. 3 & 4)
ON FARM, THE FOLLOWING OBSERVATIONS WERE ALSO MADE:
- a reduction in the incidence of problems associated with the on-farm adaptation of gilts
- a decrease in the number of cases of post-farrowing fevers in sows
MA 104 cellular culture
Cytodex (x 100,000)
When deciding whether you should be vaccinating your breeding herd against PRRS, an assessment of the level of virus circulation amongst breeders is required. The clinical signs should always be taken into account and your vet may advise taking some blood samples to test for evidence of exposure to PRRS. Such serological assays of a representative sample of the herd (piglets, fatteners, gilts & sows) will provide a clearer picture of the PRRS status of the stock.
Vaccination with PROGRESSIS will normally be recommended in herds where there is evidence of active circulation of the PRRS virus amongst breeding pigs.
PROGRESSIS is an oil-adjuvanted inactivated vaccine intended for use in breeding pigs.
PROGRESSIS boosts and homogenises the immunity of the breeding herd and helps to limit circulation of the virus.
Gilts: 2 injections at a 3 ? 4 week interval given at least 3 weeks before the first service
Sows: 2 injections 3 ? 4 weeks apart at any stage of production (vaccination of all sows in
the herd within a short period is recommended)
1 injection between days 60 ? 70 of gestation starting with the first pregnancy following primary vaccination
2 ml by intramuscular injection
||THE SAFE, SURE SOLUTION TO RESTORE BALANCE TO YOUR HERD?S HEALTH
WHERE PRRS IS A PROBLEM, PROGRESSIS
IMPROVES PRODUCTIVITY AND THE SMOOTH
RUNNING OF THE UNIT.
PROGRESSIS IS A KEY WEAPON FOR THE
CONTROL OF THE DISEASE ON THE FARM.
The Legal Bit
PROGRESSIS®. Presentation: Each dose of 2 ml contains: Inactivated PRRS virus (European strain): 2.5 log10 IF units, o/w Oily excipient, q.s.2
ml, Gentamicin: traces. Indications for use. Reduction of the reproductive disorders caused by Porcine Reproductive and Respiratory Syndrome
virus (European strain) in a contaminated environment: vaccination of sows and gilts reduces the number of early farrowings and the number of
stillbirths. Dosage and administration: One dose of 2 ml is administered by deep intramuscular route, in the neck muscles behind the ear,
according to the following vaccination scheme: Primary vaccination: Gilts: 2 injections 3-4 weeks apart, at least 3 weeks before mating.
Sows: 2 injections 3-4 weeks apart (Vaccination of all the sows of the herd within a short period is recommended). Revaccination: One injection
at day 60-70 of gestation, starting with the first pregnancy following primary vaccination. Contra-indications, warnings, etc.: For animal
treatment only. There are no known contraindications. Apply the usual aseptic procedures. Vaccinate only healthy animals. Apply the usual
procedures for the handling of animals. Vaccination may induce a transient oedema (at most 3 cm) lasting generally less than one week, and
small local reactions (granulomas), without any effect on the health and reproductive performance of the animals. Larger reactions (up to 7 cm
diameter) have been observed occasionally after frequent repeated revaccination. Vaccination may rarely cause hypersensitivity reactions. In such
cases, an appropriate symptomatic treatment should be carried out. No undesirable effect has been observed in trials after the administration of
the vaccine in pregnant or lactating animals. No adverse effect on the serological response has been observed when the vaccine is administered
simultaneously, but via a separate site, with Merial?s range of inactivated vaccines against porcine parvovirus, swine influenza, and Aujeszky?s
disease. It is recommended that no other vaccine should be administered at the same time as the product. Withdrawal period: Zero days.
Operator Safety: In case of accidental injection, seek medical advice immediately and show the package insert to the physician.
To the user: This product is a mineral oil-based compound. Accidental self-injection may result in severe pain and swelling and could result in
the loss of the affected finger or thumb if prompt medical attention is not given. Ensure that the method of restraint, handling and administration,
e.g. by the use of guarded needles, minimizes the risk of accidental injection/self injection. If you are accidentally injected with this product, clean
and disinfect the wound immediately. Go AT ONCE to the nearest accident and emergency (casualty) department of a hospital and show the
information printed below to the doctor (or nurse) on duty. Seek prompt medical advice even if only a very small amount is injected. If pain
persists for more than 12 hours after medical examination, seek further medical advice. To the Doctor: Even if very tiny amounts have been
injected, accidental injection with this oil-based product is particularly irritating. The accidental injection can cause intense swelling which may,
for example, result in ischaemic necrosis and the loss of a digit in exceptional cases. Expert, PROMPT, surgical attention is required and may
necessitate early incision and irrigation of the injected area, especially where there is involvement of finger pulp or tendon. Pharmaceutical
precautions: Keep out of reach of children. Use immediately after opening. Shake before use. Do not mix with any other medicinal product. Store
at 2?C ? 8?C (in a refrigerator), protected from light. Any unused product or waste material should be disposed of in accordance with national
requirements. Legal category: POM. Package quantities: Box of 1 bottle of 5 doses. Box of 1 bottle of 25 doses. Further information: In PRRS
infected herds, viral infection is heterogeneous and varies over time. In such context, the implementation of a vaccination program is a tool to
improve the reproductive parameters and may contribute to the overall disease control in conjunction with sanitary measures. Marketing
Authorization Number: Vm 08327/4204
PROGRESSIS is an inactivated PRRS vaccine for breeding sows and gilts. POM PROGRESSIS is available through your
veterinary surgeon. Read package insert before use. For further information contact your veterinary surgeon or call
MERIAL on FREEPHONE 0800 592699. Or visit our website www.merial.com Merial A.H. Limited, PO Box 327,
Harlow, Essex CM19 5TG. ? Registered trademark of Merial. ? Merial 2001. All rights reserved.
Usage instructions & withdrawal periods may vary by Country.
Always follow label instructions.
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