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Bulletin No. 18 - Spring 2004
VirologyPMWS-PCV2-PCVD-PDNS
FENAUX M, OPRIESSNIG T, HALBUR PG, MENG XJ
Immunogenicity and pathogenicity of chimeric infectious DNA clones of pathogenic porcine circovirus type 2 (PCV2) and nonpathogenic PCV1 in weaning pigs.
Journal of Virology, October 2003, 11232-11243
The immunogenic ORF2 capsid gene of PCV2 was substituted for that of the non-pathogenic PCV1. This chimeric PCV1-2 replicated and expressed the capsid protein of PCV2 in vitro and in vivo. The capsid protein was immunogenic but the infection with the chimeric PCV1-2 induced only a limited infection with mild pathological lesions. Further studies are required to determine whether this type chimeric virus could be used in future as a vaccine against PCV2 infection and PMWS.
