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Bulletin No. 18 - Spring 2004
VirologyPMWS-PCV2-PCVD-PDNS
ELLIS J, CLARK E, HAINES D, WEST K, KRAKOWKA S, KENNEDY S, ALLAN GM
Porcine circovirus-2 and concurrent infections in the field.
Veterinary Microbiology, 98, 2004, 159-163
When reviewing the various swine diseases that currently affect the world's swine populations, the prevalence of PCV2 co-infection is a striking fact. However, the synergism between PCV2 and porcine parvovirus (PPV) which may enhance PCV2 replication but does not result necessary for the development of PMWS, the synergism between PCV2 and porcine reproductive and respiratory syndrome virus (PRRSV), Mycoplasma hyopneumoniae or swine influenza virus (SIV) which are frequently reported as co-factors in porcine respiratory disease complex (PRDC), as well as the involvement of PCV2 in hepatic, enteric and renal diseases are not fully understood. An hypothesis is that co-infecting agents would cause the death of cells leading to the regeneration of damaged tissue and an increase of the actively replicating cell population used by PCV2 to replicate. This would result in an increase of the viral load and the expression of the disease. Besides, an increased occurrence of parasitosis (Pneumocystis carinii) in PMWS-affected pigs indicates a potential immunosuppressive effect of PCV2 infection.
