Swine Bibliography Centre
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Bulletin No. 18 - Spring 2004
VirologyPMWS-PCV2-PCVD-PDNS
PENSAERT MB, SANCHEZ RE, LADEKJ?R-MIKKELSEN AS, ALLAN GM, NAUWYNCK HJ
Viremia and effect of fetal infection with porcine viruses with special reference to porcine circovirus 2 infection.
Veterinary Microbiology, 98, 2004, 175-183
The pathogenesis of transplacental infections with porcine viruses in sows is briefly reviewed, followed by a comprehensive report of the results of several experiments of PCV2 infection in pregnant sows. PCV2 was shown to cause viremia. Both the cell-free and PMBC-associated forms of viremia were demonstrated but the PMBC-associated form is largely more prominent and long-lasting. In addition, PCV2 was shown to cause fetal pathology and death without affecting the maternal physiology and pregnancy. The heart is likely to be the primary target organ once PCV2 has entered fetuses. Intra-uterine virus spread was found to occur rather slowly.
