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Bulletin No. 17 - Winter 2003
VirologyPMWS-PCV2-PCVD-PDNS
GILPIN DF, MC CULLOUGH K, MEEHAN BM, MC NEILLY F, MC NAIR I, STEVENSON LS, FOSTER JC, ELLIS JA, KRAKOWKA S, ADAIR BM, ALLAN GM
In vitro studies on the infection and replication of porcine circovirus type 2 in cells of the porcine immune system.
Veterinary Immunology and Immunopathology, 2003, Volume 94, 149-161
The detection of PCV2 nucleic acid and/or antigens in monocytes and macrophages of pigs affected with PMWS clearly shows that the virus interacts with monocytic cells. However, even if monocytic cells allow the persistence of PCV2, they do not support viral replication and seem to be involved only in the dissemination of the virus in the host. PCV2 is likely to bypass the immune system and remain silent until immunomodulatory signals trigger the expression of the disease.
