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Bulletin No. 16 - Fall 2003
Fourth International Symposium on Emerging and Re-emerging Pig diseasesPorcine Reproductive and Respiratory Syndrome (PRRS)
NIELSEN J, B?TNER A, AASTED B, JOHNSEN CK, RIBER U, TINGSTEDT JE, LIND P
In utero infection with PRRSV affects immune functions of surviving piglets.
Proceedings of the 4th International Symposium on Emerging and Re-emerging Pig Diseases, 2003, 47-48
Piglets born of PRRSV experimentally infected sows (inoculation at 90 days of gestation) were submitted to virological, serological, hematological and immunological examination prior uptake of colostrum and every two weeks until 6 weeks of age, the results were then confronted to those obtained in control piglets born of sham-inoculated sows. The immune cell population results deeply altered in surviving infected piglets. CD8+ cells in particular, are of great interest since they are clearly involved in the control of PRRSV replication. The analysis of bronchoalveolar lavage fluid also suggests interferon gamma and IL-10 as protagonists in immunity to PRRSV. In infected piglets, peripheral blood mononuclear cells (PBMC) capacity of phagocytosis proved to be inhibited, which illustrates the lack of immune response PRRSV finds when infection occurs. In addition, the interaction of PRRSV with the immune system predisposes infected animals to secondary infections.
