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Bulletin No. 16 - Fall 2003
Fourth International Symposium on Emerging and Re-emerging Pig diseasesPorcine Reproductive and Respiratory Syndrome (PRRS)
VAN GUCHT S, VAN REETH K, LABARQUE G, NAUWYNCK H, PENSAERT M
PRRSV infection increases CD14 expression and LSP-binding protein in the lungs : possible mechanisms of PRRSV-LPS clinical synergy.
Proceedings of the 4th International Symposium on Emerging and Re-emerging Pig Diseases, 2003, 49-50
The binding of lipopolysaccharides (LPS: endotoxins of Gram-negative bacteria) to CD14 (membrane receptors expressed in monocytes, macrophages and neutrophils) is increased by LPS-binding proteins (LBP). The aim of this study was to confirm or reject the hypothesis that PRRSV infection increases CD14 expression and LBP in the lungs and induces sensitization for LPS. To this end, CD14 and LBP were quantified throughout PRRSV infection. The results clearly show an increased expression of CD14 receptors by monocytes-macrophages and increased LBP, suggesting that this mechanism may account for at least part of sensitization to LPS. A following exposure to LPS will thus result in the production of proinflammatory cytokines and respiratory signs.
