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Bulletin No. 16 - Fall 2003
Fourth International Symposium on Emerging and Re-emerging Pig diseasesPorcine Reproductive and Respiratory Syndrome (PRRS)
SURADHAT S, THANAWONGNUWECH R
Upregulation of IL-10 gene expression in the peripheral blood mononuclear cells (PBMC) of pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV).
Proceedings of the 4th International Symposium on Emerging and Re-emerging Pig Diseases, 2003, 83-84
In vitro, upregulation of IL-10 due to PRRSV has been shown to negatively alter the immune functions of peripheral blood mononuclear cells (PBMC). This study confirms the same effect of PRRSV in vivo: rapidly stimulating the production of an immunosuppressive cytokine such as IL-10, PRRSV hampers the host immune responses and induces only a weak innate immunity.
