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Bulletin No. 16 - Fall 2003
Fourth International Symposium on Emerging and Re-emerging Pig diseasesPorcine Reproductive and Respiratory Syndrome (PRRS)
NILUBOL D, THACKER BJ, HARRIS DL, THACKER EL
PRRSV vaccination study: interleukin-12 to enhance killed vaccine immunity and combined vaccination with modified live and killed vaccines.
Proceedings of the 4th International Symposium on Emerging and Re-emerging Pig Diseases, 2003, 113-114
Several vaccination protocols were compared in order to assess their ability to induce immune responses: PRRSV killed vaccine (KV) alone, PRRSV KV added IL-12, PRRSV modified live vaccine (MLV) alone and PRRSV MLV combined with PRRSV KV. All treatments groups were challenged intranasally with PRRSV. Investigations were based on ELISA, seroneutralization and lymphocyte proliferative responses. The use of IL-12 added to PRRSV KV failed to enhance immune responses. In addition, the results show that the combined MLV and KV protocol allows more rapid antibody and cell-mediated immunity responses. Further investigations in this direction are needed.
