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Bulletin No. 16 - Fall 2003

Fourth International Symposium on Emerging and Re-emerging Pig diseases

PMWS-PCV2-PCVD-PDNS

VINCENT IE, CARRASCO CP, HERRMANN B, MEEHAN B, ALLAN GM, SUMMERFIELD A, MAC CULLOUGH KC
Dendritic cells: a Trojan horse for porcine circovirus type 2?
Proceedings of the 4th International Symposium on Emerging and Re-emerging Pig Diseases, 2003, 163

The results of this study show that:
  • PCV2 does not replicate in dendritic cells (DCs)
  • PCV2-infected DCs do not alter the expression of surface markers in monocyte-derived DCs nor in bone-marrow-derived DCs.
  • infected DCs do not transmit PCV2 infection to T lymphocytes, nor induce PCV2 replication in DCs.
Therefore, a direct interaction between dendritic cells and lymphocytes cannot account for the process of immunosuppression due to PCV2 infection.


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