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Bulletin No. 16 - Fall 2003
Sixth International Congress of Veterinary Virology - Saint-Malo (France)- No Category
BARANOWSKI E, RUIZ-JARABO CM, PARIENTE N, VERDAGUER N, DOMINGO E
Evolutionary aspects of cell recognition by viruses.
Proceedings of the 6th International Congress of Veterinary Virology, 2003, 32-34
One specific cell receptor can be used by viruses that belong to distant families and closely related viruses can use different receptor types. Consequently, there is no obvious correlation between the two, so that virus-receptor interactions are unpredictable and are to be studied individually. Some DNA viruses, such as poxviruses and herpesviruses, take advantage of their genome complexity to deceive the immune system imitating chemokines or chemokine receptors. Other DNA viruses have at their disposal various molecules to interact with different cell receptors and switch cell tropism. RNA viruses play the card of adaptability with high mutation rates. In addition, viruses that use some receptors in vivo may develop alternative strategies to interact with different receptors in vitro, as it is the case for classical swine virus in swine kidney cells. In vitro, these shifts of receptor usage may be associated with adaptation to new hosts. Foot-and-mouth disease is mentioned as an example of remarkable flexibility in receptor usage. Such a process has already been shown to also occur in vivo and represents a major source of concern regarding the emergence of human and animal diseases.
