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Bulletin No. 16 - Fall 2003
Sixth International Congress of Veterinary Virology - Saint-Malo (France)- No Category
VAN REETH K, PENSAERT M
Porcine repiratory coronavirus: a SARS model to be considered.
Proceedings of the 6th International Congress of Veterinary Virology, 2003, 47
Pathogenesis of porcine respiratory coronavirus (PRC) is reviewed and compared with that of severe acute respiratory syndrome (SARS) coronavirus. PRC derives from swine transmissible gastroenteritis virus (TGEV) by deletion but shows a pronounced tropism for the respiratory tract. PRC in itself induces only mild respiratory signs but can contribute to multifactorial respiratory disease, in particular when combined with lipopolysaccharides of E. coli, this combination may be an interesting model to study multifactorial respiratory disease. An hypothesis is that, in fact, SARS may be a multifactorial disease with SARS coronavirus (SARS-coV) as primary agent. PRC is thus considered as a valuable model to study the pathogenesis of SARS-coV.
