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Bulletin No. 16 - Fall 2003
Sixth International Congress of Veterinary Virology - Saint-Malo (France)- No Category
VAN REETH K, LABARQUE G, BROWN I, PENSAERT M
Cross-protection studies in pigs with serologically distinct swine influenza virus subtypes.
Proceedings of the 6th International Congress of Veterinary Virology, 2003, 72
Cross-protection was already demonstrated to occur against H1N2 following successive infection with the H1N1, H3N2 and H1N2 subtypes. The objective of this study was to determine whether cross-protection is also provided when pigs are exposed to the same subtypes but in another sequence. Infection-induced immunity against any of the 3 subtypes provided partial cross-protection against the other subtypes. Interestingly, cross-protection was considerably enhanced in case of a dual infection. The results also show that cross-protection may depend on non-neutralizing cross-reactive antibodies against viral proteins distinct from haemagglutinin (HA). In addition, the high percentage of homogeneity detected between the various subtypes suggests that nucleoproteins and matrix proteins may be involved in cellular immunity.
