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Bulletin No. 16 - Fall 2003
VirologyPorcine Reproductive and Respiratory Syndrome (PRRS)
VANDERHEIJDEN N, DELPUTTE PL, FAVOREEL HW, VANDEKERCKHOVE J, VAN DAMME J, VAN WOENSEL PA, NAUWYNCK J
Involvement of sialoadhesin in entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages.
Journal of Virology, 2003, Volume 77, N?15, 8207-8215
The results of this study together with those of previous experiments show that:
- Mab41D3 (monoclonal antibody which binds specific receptors present on macrophage surface membrane) was shown to recognize porcine sialoadhesins on porcine alveolar macrophages (PAMs) and to prevent PRRSV infection of PAMs;
- PK-15 cells, when they are modified so as to express sialoadhesins on their membrane, are no more resistant to PRRSV-infection;
- MAb41D3 recognized sialoadhesins in all PRRSV-infected cells from experimentally infected pigs, showing that all these cells do express sialoadhesins;
- MAb41D3 was internalized by encytosis into PAM, showing that sialoadhesins are involved in the process of endocytosis.
