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Bulletin No. 16 - Fall 2003
VirologySwine Influenza
VAN REETH K, VAN GUCHT S, PENSAERT M
Investigations of the efficacy of European H1N1- and H3N2-based swine influenza vaccines against the novel H1N2 subtype.
Veterinary Records, 2003, Volume 153, N?1, 9-13
Two vaccinated groups and one control group of pigs were included in this study. Pigs of the two vaccinated groups were vaccinated twice, at four and eight weeks of age, group one with a H1N1/H3N2 vaccine (Gripovac?, Merial), group two with the same vaccine supplemented with an H1N2 component. All pigs were challenged with a H1N2 strain three weeks later. H1N1/H3N2 commercial vaccine did not prevent H1N2 virus replication but pigs from group one showed milder respiratory signs in comparison to control pigs. In contrast, pigs that were vaccinated with the H1N2-supplemented vaccine showed no respiratory signs and virus replication was not detected at 72 hours post-challenge. The investigated vaccine did not provided a sufficient protection against H1N2 subtype.
