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Bulletin No. 15 - Summer 2003
VirologyPorcine Reproductive and Respiratory Syndrome (PRRS)
SHIBATA I, YAZAWA S, ONO M, OKUDA Y
Experimental dual infection of specific pathogen-free pigs with porcine reproductive and respiratory syndrome virus and pseudorabies virus
J Vet Med 2003 50: 14-19
An experimental dual intranasal infection of PRRSV (porcine reproductive and respiratory syndrome virus) and PRV (pseudorabies virus) induced more severe clinical signs and pneumonia lesions in six-week old SPF pigs than PRRSV alone. A fourth group was kept as control group. At necropsy, study of gross and histopathological lesions revealed that severe interstitial pneumonia and lung lesions were observed in the PRRSV-PRV group while the other inoculated groups had mild lesions. Higher antibody titres and a prolonged fever were recorded for the dually infected group. This experiment supports previous studies demonstrating that concurrent infections with two pathogens can enhance clinical signs of these infections in pigs.
