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Bulletin No. 15 - Summer 2003
VirologyPorcine Reproductive and Respiratory Syndrome (PRRS)
MENGELING WL, LAGER KM, VORWALD AC, KOEHLER KJ
Strain specificity of the immune response of pigs following vaccination with strains of porcine reproductive and respiratory syndrome viru
Vet Microbiology 2003 93: 13-24
A phenomenom of strain exclusion was noteworthy in this experiment. Five groups (I-V) of six pigs each were selected. Groups III to V were vaccinated intramuscularly with attenuated strains of PRRS (8, 9 and 14). Twenty-one days later, groups II to groups V were oronasally exposed to a virulent counterpart of the vaccine strain. Group I was kept as a control group. Virus and antibody identifications were performed after vaccination and after exposure to the virulent PRRSV. It is interesting to note that for groups vaccinated and challenged with strains 8 or 9, the most commonly identified strain after challenge was strain 14. Conversely for group V vaccinated and challenged with strain 14, mainly strain 8 was isolated after challenge. This phenomenom of homologuous strain exclusion following vaccination was significant and needs to be further investigated to study its impact on immune protection.
