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Bulletin No. 15 - Summer 2003
VirologyPMWS-PCV2-PCVD-PDNS
OKUDA Y, ONO M, YAZAWA S SHIBATA I
Experimental reproduction of postweaning multisystemic wasting syndrome in cesarean-derived, colostrum-deprived piglets inoculated with porcine circovirus type 2 (PCV2) : investigation of quantitative PCV2 distribution and antibody responses
J Vet Med 2003 15:107-114
In this experiment, PMWS was reproduced in four piglets inoculated with PCV2 and in one contact piglets. The remaining 15 piglets (2 uninoculated contact piglets, 2 control piglets and 11 inoculated piglets) did not show any clinical signs or gross histopathological lesions typical of PMWS (icterus, lymphocyte depletion, basophilic intraplasmic inclusion bodies and hepatocellular necrosis) while the five PMWS-affected piglets did. Interestingly, PMWS developed in piglets infected with only PCV2. No other swine pathogens were present. PCV2 was recovered in the serum, swabs and tissue samples of non-symptomatic PCV2 infected piglets as well as symptomatic piglets. However, the quantitative distribution of PCV2 was greater in PMWS piglets than in infected but healthy piglets (in lymph nodes, lymphoid tissues but also in lung, liver, small intestine, kidney) and their antibody response was delayed until 28 days post infection (compared to 14 and 21 days post infection for non- symptomatic piglets). The role of virus quantification needs to be further studied to undestand how it appears to trigger PMWS.
