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Bulletin No. 19 - Fall 2004
18th IPVS Congress, Hamburg, Germany, 2004PMWS-PCV2-PCVD-PDNS
NIELSEN J, LADEKJÆR HANSEN AS, BILLE-HANSEN V, LOHSE L, BØTNER A
PCV2-associated disease following intrauterine infection
Proceedings of the 18th IPVS Congress, Hamburg, Germany, 2004 - Volume 1:14
Two PCV2-seropositive gilts were inoculated intranasally with PCV2 at 72 and 92 days of gestation respectively. Piglets born of these two gilts were blood sampled prior colostrum intake and then weekly until 5 weeks of age. They were followed clinically and necropsied. Tissue samples were submitted to virological and histopathological examination and immunohistochemical detection of PCV2. The presence of PCV2-antigen was investigated in serum from the 2 gilts and their piglets by quantitative PCR. Intrauterine infection did take place in one of the two gilts (gilt inoculated at 72 days of gestation) demonstrating that PCV2 can cross the transplacental barrier. In addition, PCV2-infected liveborn piglets died from PCV2-associated lesions during the experiment which indicates that PCV2-associated diseases can occur following intrauterine infection with PCV2. Since semen was not checked for PCV2 contamination, a possible contamination through this iroute can not be absolutely ruled out.
