Possible prevention of PMWS using inactivated PCV2 vaccine in CDCD pigs

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Bulletin No. 19 - Fall 2004

18th IPVS Congress, Hamburg, Germany, 2004

PMWS-PCV2-PCVD-PDNS

POGRANICHNIY R, YOON KJ, YAEGER M, VAUGHN E, HARMON K, STAMMER R, ROOF M
Possible prevention of PMWS using inactivated PCV2 vaccine in CDCD pigs
Proceedings of the 18th IPVS Congress, Hamburg, Germany, 2004 - Volume 1:55

The safety and efficacy of two experimental PCV2 vaccines inactivated either by chemical process (BEI) or ultraviolet (UV) irradiation were evaluated in caesarian derived colostrum deprived (CDCD) pigs. Co-infection and immunostimmulation were respectively reproduced with an injection of PRRSV and an injection of keyhole limpet hemocyanin (KLH) combined with incomplete Freund's adjuvant. All groups but one were challenged with PCV2 at day 24. The treatment groups were as follows:

	1	2	3	4	5	6
D0	UV	BEI
D7	PRRSV	PRRSV	PRRSV
D14	UV	BEI
D21				KLH
D24	PCV2	PCV2	PCV2	PCV2	PCV2
D27				KLH
%MORTALITY	20%		70%		20%	0%

ADG in groups 1 and 2 was identical to that of group 6 (non-vaccinated, non-challenged pigs) whereas ADG in groups 3 and 4 was significantly lower. None of the surviving pigs of groups 1 and 2 had microscopic lesions typical of PMWS in lymph nodes and lungs and were negative for PCV2 by IHC whereas all surviving pigs of group 5 showed microscopic lesions and were PCV2-positive. PCV2 inactivated vaccines may be a way of minimizing PCV2-associated diseases.

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Bulletin No. 19 - Fall 2004

Wednesday 8th October