Swine Bibliography Centre
|
Support that keeps you updated for FREE  |
Bulletin No. 20 - Winter 2004
VirologyPorcine Reproductive and Respiratory Syndrome (PRRS)
ZHOU EM, CLAVIJO A, JIANG Z, AMERI-MAHABADI M, ZIMMERMAN JJ
Induction of auto-anti-idiotypic antibodies specific for antibodies to matrix and envelope glycoprotein from pigs experimentally infected with porcine reproductive and respiratory syndrome virus.
Veterinary Immunology and Immunopathology, 2004, Volume 101, Nº1-2, 49-59
The production of auto-anti-idiotypic antibodies (Aab-2s) acts as a feedback mechanism which neutralizes the idiotypes of the antibodies generated against an infectious agent and thus controls the immune response. The experimental infection of 47 pigs with a US strain of PRRSV provided evidence that Aab-2s against anti-GP5 antibodies and anti-M antibodies were induced. Interestingly, non-virus carrier pigs and virus carrier pigs had a distinct Aab-2s response. Indeed, non-virus carriers showed an early peak of Aab-2s (at 35 DPI) while virus carriers had a later peak of Aab-2s (at 77DPI). The detection and characterization of Aab-2s may represent a valuable tool in order to anticipate whether PRRSV-infected pigs will remain persistently infected or not.
