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Bulletin No. 22 - Summer 2005
VirologyPMWS-PCV2-PCVD-PDNS
OPRIESSNIG T, THACKER EL, YU S, FENAUX M, MENG XJ, HALBUR PG
Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2.
Veterinary Pathology, 2004, Volume 41, N°6, 624-640
The intratracheal inoculation of Mycoplasma hyopneumoniae at 4 weeks of age followed by the intranasal inoculation of PCV2 at 6 weeks of age in pigs resulted in the potentiation of the severity of PCV2-associated lung and lymphoid lesions, in an increased amount and prolonged presence of PCV2 antigen and an increased incidence of PMWS in dual-infected pigs compared with the singular PCV2-inoculated group. This dual-infection model indicates that a lack of control of M. hyopneumoniae infection through vaccination may be more detrimental than a vaccine-induced enhancement of PCV2 replication.
