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Bulletin No. 25 - Summer 2006
MiscelleanousNutrition
SPRING P
Pronutrient series Part 3. The Study of sugars within organisms.
Pig Progress, 2005, Volume 21, N°6, 10-11
The set of carbohydrates of an organism, i.e. the “glycome”, arouses great interest among researchers as a new way to explore in order to control infectious and non-infectious diseases. Carbohydrates are involved in the initial process of infection by bacteria (host cell adhesion) and viruses (attachment and penetration). The integration of mannan oligosaccharides (MOS) in the diet of swine has already been shown to reduce the prevalence and concentration of various enteropathogenic bacteria such as salmonella, E.coli and clostridi. Moreover, MOS also play a role in reducing cell-to-cell interactions between bacteria and thus, by limiting the occurrence of conjugation, impair transmission of genetic material responsible for antibiotic resistance. The carbohydrate strategy may also be investigated for viral diseases as a means to limit the interaction between host cell glycoprotein receptors and virus. Other applications regarding cancer, prion diseases and anti-inflammatory drugs are also promising.
