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Bulletin No. 26 - Fall 2006
VirologyPorcine Reproductive and Respiratory Syndrome (PRRS)
CHO JG, DEE SA, DEEN J, GUEDES A, TRINCADO C, FANO E, JIANG Y, FAABERG K, COLLINS JE, MURTAUGH MP, JOO HS
Evaluation of the effects of animal age, concurrent bacterial infection, and pathogenicity of porcine reproductive and respiratory syndrome virus on virus concentration in pigs.
American Journal of Veterinary Research, 2006, Volume 67, Nº3, 489-493
The impact of age, concurrent bacterial infection and virulence of PRRSV on the concentration of PRRSV in blood, nasal and oropharyngeal secretions, and in a panel of tissues was evaluated by quantitative real-time PCR in pigs aged 2 and 6 months. All three factors were demonstrated to affect PRRSV concentrations: pigs infected with highly virulent PRRSV had higher viral loads than those infected with mildly virulent PRRSV, so did pigs infected with both virulent PRRSV and Mycoplasma hyopneumoniae (lymphoid and tonsillar tissue). Independently of the virulence of PRRSV, higher viral loads were also detected in pigs with concurrent M. hyopneumoniae infection (blood and oropharyngeal secretions) and younger pigs (lymph nodes, lungs, tracheal secretions). Thus, PRRSV concentration in pigs results from multiple factors including age, concurrent bacterial infection and virulence of the PRRSV isolate.
