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Bulletin No. 26 - Fall 2006
VirologyPorcine Reproductive and Respiratory Syndrome (PRRS)
SURADHAT S, KESDANGSAKONWUT S, SADA W, BURANAPRADITKUN S, WONGSAWANG S, THANAWONGNUWECH R
Negative impact of porcine reproductive and respiratory syndrome virus infection on the efficacy of classical swine fever vaccine.
Vaccine, 2006, Volume 24, Nº14, 2634-2642
The influence of porcine reproductive and respiratory syndrome virus (PRRSV) infection on the efficacy of classical swine fever (CSF) vaccination was assessed in terms of clinical signs, virological findings, macroscopic lesions, immune response and cytokine production, in 17-day-old pigs according to the following protocol: the animals were first inoculated with a US genotype Thai PRRSV, then administered a CSF vaccine one week later and challenged with a virulent CSF virus 3 weeks following vaccination. They were subsequently compared to four control groups (no PRRSV infection, no CSFV vaccination, no PRRSV infection/CSFV vaccination, no PRRSV infection/CSFV vaccination/challenge). A negative impact of PRRSV infection on the immune response of CSFV-vaccinated pigs was clearly demonstrated since it was associated to vaccine failure upon challenge with CSFV with clinical signs, viremia, and macroscopic lesions similar to those of the non-vaccinated groups.
