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Bulletin No. 26 - Fall 2006
VirologySwine Influenza
KIM WI, WU WH, JANKE B, YOON KJ
Characterization of the humoral immune response of experimentally infected and vaccinated pigs to swine influenza viral proteins.
Archives of Virology, 2006, Volume 151, Nº1, 23-36
The ever-changing influenza viruses are a continuous diagnostic challenge due to the wide variety of subtypes emerging thanks to mutations and recombinations of their RNA genome via a process of antigenic drifts and shifts. The already-complex interpretation of serologic tests for the diagnosis of swine influenza virus (SIV) infection is further complicated by vaccination. In this context, which SIV protein can be used to differentiate between vaccinated and infected pigs? This paper reports the characterization of the humoral response to specific viral proteins in SIV vaccinated and SIV infected pigs by Western immunoblot. While infected pigs did produce antibodies against non-structural (NS) protein 1, vaccinated pigs did not, suggesting that NS1 protein may be used to design a serologic method allowing the differentiation between vaccinated and infected pigs.
