Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells.

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Bulletin No. 27 - Summer 2007

Virology

PMWS-PCV2-PCVD-PDNS

MISINZO G, DELPUTTE PL, MEERTS P, LEFEBVRE DJ, NAUWYNCK HJ
Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells.
Journal of Virology, 2006, Volume 80, N°7, 3487-3494

Several considerations led the authors to examine the potential role of surface glycosaminoglycans (GAG) as receptors for porcine circovirus type 2 (PCV2):

other viruses are already known to use GAG as binding receptors to achieve cell infection,
GAG are present on many types of cells which is consistent with the fact PCV2 achieves infection in a wide range of cell types,
All PCV2 isolates show a conserved molecular motif including heparan sulfate (HS) in their capsid protein.

In this study, several approaches such as competition or interaction experiments and enzymatic GAG removal allowed to demonstrate that HS and chondroitin sulfate B (CS-B) are used by PCV2 as attachment cell receptors.

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Swine Bibliography Centre

Bulletin No. 27 - Summer 2007

Monday 1st December