Effects of adjuvants on porcine circovirus type 2-associated lesions.

Swine Bibliography Centre

ThePigSite.com Swine
Bibliography
Centre
is brought to you in association with
Merial

Support that keeps you updated
for
FREE

Bulletin No. 27 - Summer 2007

Virology

PMWS-PCV2-PCVD-PDNS

HOOGLAND MJ, OPRIESSNIG T, HALBUR PG
Effects of adjuvants on porcine circovirus type 2-associated lesions.
Journal of Swine Health and Production, 2006, Volume 14, N°3, 133-139

Do adjuvants have an impact on the severity on PCV2-induced lesions? To answer this question, 90 pigs were included in this experimental study, distributed into 5 groups and vaccinated at 4 and 6 weeks of age with 2ml of a commercial Mycoplasma hyopneumoniae vaccine:

group 1: oil-in-water adjuvant (Respisure®, Pfizer Animal Health Inc)
group 2: aqueous carbopol adjuvant (Suvaxyn Respifend MH®, Fort Dodge Animal Health Inc)
group 3: oil-in-water adjuvant (experimental vaccine)
group 4: aluminum hydroxide adjuvant (experimental vaccine)
group 5: saline (sham vaccination)

PCV2 was inoculated intranasally to all pigs at 6 weeks of age. Half of them were necropsied on day 21 post-inoculation (PI) and the other half on day 35 PI. On day 21 PI, all vaccinated groups showed more severe lymphoid depletion than the shamed-vaccinated group. On day 35 PI, larger amounts of PCV2 DNA and PCV2 antigen were found respectively in serum and lymphoid tissues, together with more severe lymphoid lesions in pigs that had received oil-in-water adjuvanted vaccine (groups 1 and 3). Taken together these results suggest that oil-in-water adjuvants enhance PCV2-associated lesions.

Other Web Sites
	ThePoultrySite
	TheFishSite
	TheBioenergySite
	TheCattleSite
	TheBeefSite
	TheDairySite

	ThePigSite.cn
	ThePoultrySite.cn
	TheFishSite.cn

Swine Bibliography Centre

Bulletin No. 27 - Summer 2007

Monday 1st December