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Bulletin No. 28 - Winter 2007
VirologySwine Influenza
THAKER EL, KITIKOON P, YAGER G, STRAIT E, YU S, JANKE B
Investigation of the ability of the M2 protein to enhance cross protection against different SIV isolates.
Proceedings of the 19th IPVS Congress, Copenhagen, Denmark, 2006 - Volume 1:268
The aim of this study was to assess whether a swine influenza virus (SIV) vaccine (bivalent H1N1/H3N2 vaccine, EndFLUence®-2, Intervet, Inc.) associated with a recombinant M2 protein conferred a good protection against infection. Crossbred PRRSV and SIV negative pigs were selected for the study. They were randomly assigned to 7 different groups and vaccinated/challenged as follows:
Clinical signs were monitored and SIV hemagglutinin-inhibition antibodies were measured before necropsy. Lung lesions were then assessed and SIV antigens detected by immunohistochemistry (IHC). A non-parametric Rank sum test was used to analyse the data collected. The results could not clearly confirm that the rM2 protein conferred a higher protection against infection
