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Bulletin No. 29 - Spring 2008
VirologyPMWS-PCV2-PCVD-PDNS
KIM J, HA Y, CHAE C
Potentiation of porcine circovirus 2-induced postweaning multisystemic wasting syndrome by porcine parvovirus is associated with excessive production of tumor necrosis factor-alpha.
Veterinary Pathology, 2006, Volume 43, Nº5, 718-725
The aim of this study was to determine the level of tumor necrosis factor (TNF)-a produced in vitro in case of single infection with either porcine circovirus type 2 (PCV2) or porcine parvovirus (PPV) or co-infection with both viruses. Thirty-two pigs free from PPV, PCV and PRRSV, were selected for the study and randomly allocated to 4 groups. One group was used as negative controls. Pigs in the first group were challenged with PCV2; pigs in the second group were challenged with PPV and pigs in the third group were challenged with both PPV and PCV2. Body weight was monitored. Blood samples were regularly collected and levels of TNF-a were quantified with an ELISA test. The results suggested that a correlation did exist between an excessive production of TNF-a and the potentiation of PCV2-induced PMWS by PPV.
