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Bulletin No. 29 - Spring 2008
VirologyPorcine Reproductive and Respiratory Syndrome (PRRS)
SCORTTI M, PRIETO C, MARTíNEZ-LOBO FJ, SIMARRO I, CASTRO JM
Effects of two commercial European modified-live vaccines against porcine reproductive and respiratory syndrome viruses in pregnant gilts.
The Veterinary Journal, 2006, Volume 172, 506-514
The objective of this case-control study was to investigate the effects of two European-type modified-live vaccines (MLV) against porcine reproductive and respiratory syndrome viruses (PRRSV) on pregnant gilts. Sixteen pregnant gilts were selected for the study and randomly allocated to four groups. Group A was used as negative control. Group B gilts received a virulent field strain. Group C gilts received one vaccine strain and Group D gilts received another vaccine strain. Clinical signs, rectal temperature and food intake were monitored. Blood samples were regularly collected from gilts, but also from piglets born to studied gilts. Necropsies were carried out and several tissue samples were collected. Antibodies against PRRSV were detected with an ELISA test. The virus was detected with an RT-PCR and titres were also assessed. The results showed that none of the MLV had negative effects on pregnant gilts but that these strains could however cross the placental barrier. Piglets can therefore be congenitally infected and this is why the use of MLVs should be limited in pregnant gilts and ideally restricted to non-pregnant animals.
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