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Bulletin No. 30 - Summer 2008
BacterologyHelicobacter
KRAKOWKA S, ELLIS J
Reproduction of severe gastroesophageal ulcers (GEU) in gnotobiotic swine infected with porcine Helicobacter pylori-like bacteria.
Veterinary Pathology, 2006, Volume 43, N°6, 956-962
The deleterious effect on the digestive tract of gastric colonization with fermentative bacteria (Lactobacillus and Bacillus spp.) combined with a dietary source of carbohydrates was previously demonstrated. This time, the role of Helicobacter pylori (Hp)-like bacterium in the production of gastroesophageal ulcers (GEU) in piglets was investigated. At three days of age, one group of piglets (n=9) was orally inoculated with Helicobacter heilmannii (Hh), a second group (n=11) with porcine Hp-like bacteria and a third group (n=2) with a Brucella broth (controls). Three of the Hh-inoculated piglets and six of the Hp-inoculated piglets were fed a sow milk replacement diet supplemented with a source of fermentable liquid carbohydrate (corn syrup) while the remaining piglets were fed normal diet. In pigs fed replacement diet, gastric Hh colonization was not associated with gastric mucosal ulcers. By contrast, severe GEU was observed in all pigs inoculated with Hp-like bacterium and fed replacement diet, indicating a clear deleterious effect of combined high carbohydrate diet and gastric colonization by Hp-like bacterium.
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