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Bulletin No. 30 - Summer 2008
VirologyPorcine Reproductive and Respiratory Syndrome (PRRS)
WANG X, EATON M, MAYER M, LI H, HE D, NELSON E, CHRISTOPHER-HENNINGS J
Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability.
Archives of Virology, 2007, Volume 152, Nº2, 289-303
Dendritic cells (DC) are a key component of primary immunity due to their antigen presentation ability in case of viral infections. Porcine reproductive and respiratory syndrome virus (PRRSV) was shown to productively infect monocyte-derived DC (Mo-DC) resulting in cell death. In addition, the PRRSV infection of Mo-DC expression was found to down-regulate the expression of MHCI, MHCII, CD14 and CD11b/c. Such mechanisms result in immune suppression and may thus help the virus to circumvent the immune response, persist in the host and facilitate secondary infections.
