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Bulletin No. 31 - Fall 2008
MiscelleanousVaccines and Vaccination
NILUBOL D, THACKER BJ, THACKER EL
Antibody response of pigs vaccinated with modified live and killed PRRSV vaccines followed by challenge with high and low virulent strains of PRRSV
Proceedings of the 5th International Symposium on Emerging and Re-emerging Pig Diseases, 2007, 146
The purpose of this study was to investigate the antibody response triggered by a modified live (MLV) and a killed (KV) PPRSV vaccines, used either alone or in combination. A total of 55 pigs, coming from a PRRSV-free farm, were selected for the study and randomly assigned to 6 groups. Pigs from Group 1 were not vaccinated nor challenged, pigs from Group 2 were not vaccinated but challenged, pigs from Group 3 received a KV vaccine, pigs from Group 4 received an MLV vaccine, pigs from Group 5 received an MLV vaccine and then a KV vaccine, while pigs from Group 6 received first a KV vaccine and then an MLV vaccine. Half of the pigs of each group (except Group 1) were challenged with either a highly or low virulent PRRSV isolate. An ELISA test and a serum neutralization test were used to detect antibodies to PRRSV. The results indicated that a combined vaccination (preferably MLV followed by KV) triggered a rapid increase in serum neutralising antibodies and reduced viraemia and PRRSV-associated lung lesions.
