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FOR VETERINARY USE ONLY (US)
An Antimicrobial
2.3% Concentrate Solution
For Oral Use in Swine Drinking Water Only
Nuflor is used for the treatment of acute outbreaks of respiratory disease caused by strains of Actinobacillus pleuropneumoniae and Pasteurella multocida susceptible to florfenicol. Such diseases might include pneumonia, lung consolidation, lung, nasal and joint infections and meningitis.
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- Broad-Spectrum Activity1-3
Against major swine pathogens
- Fast Acting, Long Lasting4
For rapid clinical response with fewer relapses
- Unique Molecular Specificity
Designed for veterinary medicine, not humans
- Safe And Well Tolerated5
No negative impact on pig performance
Broad-Spectrum Bacterial Sensitivity1-3
| GRAM-NEGATIVE |
Actinobacillus pleuropneumoniae*
Pasteurella multocida*
Salmonella choleraesius* |
Actinobacillus suis**
Bordetella brochiseptica**
Haemophilus parasuis** |
| GRAM-POSITIVE |
Streptococcus suis Type 2*
Other Streptococci** |
| OTHERS |
Mycoplasma hyopneumoniae**
Mycoplasma hyorhinis** |
| * Swine pathogens on label have demonstrated in vivo susceptibility
to florfenicol, which correlates with clinical efficacy. |
| ** The correlation between in vitro susceptibility data and clinical
efficacy has not been determined. Refer to product insert for
specific instructions. |
- Florfenicol has a broad spectrum of antibacterial activity against both Gram-negative and Gram-positive bacteria.
Fast-Acting, Long-Lasting Therapy4
- Excellent penetration into body tissue and fluids including brains, joints, and lungs.6
- Pharmacokinetic studies of florfenicol show that Nuflor 2.3% Concentrate Solution goes to work almost immediately, reaching therapeutic concentrations in blood and tissues rapidly after administration.
- Following administration in drinking water, florfenicol concentrates remain above 1.0 µg/mL for the duration of the treatment period.
- Significantly reduces labored breathing, coughing, fever, and depression.1
Unique Molecular Spectrum
- Synthetic molecule is designed to be safe, effective, and specifically for veterinary use.
- Inhibits bacterial protein synthesis at the ribosomal level. Prevents transfer of amino acids from transfer RNA to the growing peptide chains during protein synthesis.
Proven Safety5
- Extensive variable dosage studies indicated that Nuflor 2.3 % Concentrate Solution
is well tolerated when administered according to the recommended clinical regimen.
- Nuflor has no negative impact on feed intake, water consumption, or weight gain.
Indications
Nuflor 2.3% Concentrate Solution is indicated for the treatment of swine respiratory disease associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis, and Streptococcus suis Type 2 in swine.
REFERENCES:
1. Schering-Plough study: 1370C-61-V96-301-01 & 02 and 1370C-61-V96-294
2. CC Wu, In Vitro Activity of Florfenicol against Mycoplasma hyopneumoniae and Mycoplasma hyorhinis. Final report. Purdue University, January 15, 1998.
3. Iowa State University Veterinary Diagnostic Lab: Susceptibility profile of swine pathogens, 2003
4. Schering-Plough study: 1270C-61-V97-369
5. Schering-Plough study: 96-319
6. Data on file. Schering-Plough Research Institute. SCH25298 Study# 00188.
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