Circovac - The first and only PCV2 vaccine for sows

A DEVASTATING DISEASE...

PCV2 is a highly resistant virus that compromises the immune system of pigs

It is associated with various disease syndromes, notably post-weaning multisystemic wasting syndrome (PMWS)

Common symptoms of PMWS include: piglet mortality, wasting, respiratory disease, enteritis, enlarged lymph nodes and jaundice

PCV2 can be found in pigs of all ages, all over the world: PCV2-related diseases affect both adult and growing pigs

...WITH MAJOR ECONOMIC IMPACT.

Affected herds show:

– Numbers of ‘runts’
– Mortality
– Incidence of ‘super-infections’
– Incidence of reproductive disorders

– Growth rates

UNIQUE ACTION – WORKS THROUGH THE SOW...

Maternal vaccination benefits the herd – from farrow to finish

Boosts sows’ antibody (immunity) levels

Ingestion of antibodies via colostrum protects piglets while they build their own active immunity

...PROTECTS THE WHOLE HERD.

Piglets benefit from the day of birth

Covers the vital first weeks of life

Reduced PCV2 faecal excretion lowers the viral ‘pool’ in the herd

PCV2 ANTIBODY PRODUCTION IN GILTS.

In clinical trials, blood tests confirmed vaccinated gilts produced high numbers of specific antibodies which could be transferred to their piglets via colostrum

These antibodies protect piglets from PCV2 challenge

LOWERING THE POOL OF INFECTION.

Dramatic reductions of PCV2 virus shed in faeces also lowers the environmental challenge

REDUCTIONS IN TOTAL MORTALITY.

Mortality is significantly reduced from farrow to finish

More piglets survive to produce healthy growth and profits

IMPROVED AVERAGE DAILY WEIGHT GAINS.

Large-scale field studies demonstrate that following vaccination of the sows average daily weight gains (ADWG) in the growing herd, from nursery right through to finishing, improve by up to 33g/day

Better ADWG, combined with improved feed conversion, means faster more efficient finishing

UP TO 10:1 RETURN ON VACCINATION COSTS.

Field studies demonstrate that vaccination of the sow herd can result in:

improved ADWG from farrow to finish
improved FCR from farrow to finish
lower mortalities from farrow to finish

This can mean an increase in financial returns of up to £73 or £101 per sow per year

PRIMARY VACCINATION.

Gilts:
One 2ml injection, followed 3 to 4 weeks later by a second 2ml injection, at least 2 weeks before mating One further 2ml injection must be given a minimum of 2 weeks before farrowing

Sows:
One 2ml injection, followed 3 to 4 weeks later by a second 2ml injection, at least 2 weeks before farrowing

PRODUCT DETAILER.

Circovac®
Emulsion and suspension for emulsion for injection for pigs.

Contraindications:
None.

Special warnings for each target species: None.

Special precautions for use in animals:
Vaccinate only healthy animals.Apply usual procedures for the handling of animals.Apply usual aseptic procedures.

Special precautions to be taken by the person administering the veterinary medicinal product to animals:
To the user:This product contains mineral oil. Accidental injection/self injection may result in severe pain and swelling, particularly if injected into a joint or finger, and in rare cases could result in the loss of the affected finger if prompt medical attention is not given. If you are accidentally injected with this product, seek prompt medical advice even if only a very small amount is injected and take the package leaflet with you. If pain persists for more than 12 hours after medical examination, seek medical advice again.To the physician: This product contains mineral oil. Even if small amounts have been injected, accidental injection with this product can cause intense swelling, which may, for example, result in ischaemic necrosis and even the loss of a digit. Expert, PROMPT, surgical attention is required and may necessitate early incision and irrigation of the injected area, especially where there is involvement of finger pulp or tendon.

Adverse reactions (frequency and seriousness):
Slight and transient local reactions normally occur after the administration of one dose of vaccine, mainly swelling (up to 2 cm2 in average) and redness (up to 3 cm2 in average), and in some cases oedema (up to 17 cm2 in average).These reactions resolve spontaneously in maximum 4 days on average without any consequence on the health and the zootechnical performances. In clinical studies, the post-mortem examination of the injection sites performed at most 50 days after the vaccination revealed limited lesions such as a discoloration and a granuloma in the majority of animals, as well as necrosis or fibrosis in approximately half of the animals. Within the 2 days following the injection, an average increase in rectal temperature of up to 1.4°C can occur. Rarely, an increase in rectal temperature of higher than 2.5°C, lasting less than 24 hours, may occur. In rare cases, slight apathy or reduction in appetite may be observed, which should resolve spontaneously.Vaccination may exceptionally cause hypersensitivity reactions. In such cases, an appropriate symptomatic treatment should be provided. Exceptionally abortion may occur after vaccination.

Use during pregnancy, lactation or lay:
Can be used during pregnancy. Use during lactation – not applicable.

Interaction with other medicinal products and other forms of interaction:
No information is available on the safety and efficacy from the concurrent use of this vaccine with any other. It is therefore recommended that no other vaccines should be administered concurrently within 14 days before or after vaccination with the product.

Overdose (symptoms, emergency procedures, antidotes), if necessary:

No adverse reactions except those mentioned above, were observed after the administration of a double dose of vaccine.

Withdrawal period:
Zero days.

Incompatibilities:
Do not mix with any other medicinal product.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products:
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Merial Animal Health Ltd, CM19 5TG, UK. CIRCOVAC® is a registered trademark of Merial Ltd. © Merial 2007. All rights reserved. Advice on the use of this or alternative medicines must be sought from the medicine prescriber. Legal Category: (UK) POM-V. (Ireland) POM. Read packaging before use. CIRCOVAC contains inactivated porcine circovirus type 2 (PCV2).

Further information can be obtained by calling the Merial Customer Support Centre on 0800 592699 (UK) or 1850 783 783 (Ireland).

Friday 4th July