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DENAGARD 12.5% Solution

DENAGARD 12.5% Solution is for the treatment, prevention and control of swine dysentery caused by Brachyspira hyodysenteriae and complicated by Fusobacterium and Bacteroides spp.



PAGE VERSION: INTERNATIONAL

THIS information is for Non-U.S. residents only (U.S. Residents click here) and is provided by Novartis Animal Health Inc. for general purposes only. Many veterinary products listed are available upon prescription only, and not all such products may be available in all countries. See full disclaimer below
Denagard® 12.5% solution for Pigs

Product Type

Oral antibiotic intended for preventive and therapeutic use in pigs and poultry.

Description and Composition

DENAGARD 12.5% Solution is an aqueous solution containing 125 mg tiamulin hydrogen fumarate per ml of product. It is used for medication in drinking water.

Properties

Tiamulin is a bacteriostatic agent, belonging to the group of pleuromutilins and acts at the ribosomal level to inhibit bacterial protein synthesis. It has a wide spectrum of activity but is particularly active against Brachyspira, Lawsonia and Mycoplasma species. Tiamulin belongs to a category of antibiotics which is not used in human medicine.

Indications

Treatment and prevention of Mycoplasma infections (enzootic pneumonia, chronic respiratory disease), pleuropneumonia and porcine respiratory disease complex.

DENAGARD is particularly indicated for the treatment of swine dysentery (B.hyodysenteriae)

Dosage and administration

Pigs:
  • Treatment of swine dysentery: 8.8 mg tiamulin hydrogen fumarate / kg bodyweight (equivalent to 10 ml DENAGARD 12.5% Solution per 142 kg bodyweight; inclusion level 0.006% tiamulin) for 3-5 consecutive days
  • Treatment of PRDC (porcine respiratory disease complex): 15 – 20 mg tiamulin hydrogen fumarate / kg bodyweight (inclusion level 0.012% - 0.018% tiamulin) for 5 – 10 consecutive days
  • Treatment of pleuropneumonia: 20 mg tiamulin hydrogen fumarate / kg bodyweight (inclusion level 0.018% tiamulin) for 5 consecutive days

Indications

Tiamulin (concentration in water in %)

Product
(in ml)

Water
(in liters)

Treatment
(in days)

Treatment swine dysentery

0.006

1

2.1

5

Treatment PRDC

0.012 / 0.018

1

1.0 / 0.7

5 - 10

Treatment pleuropneumonia

0.018

1

0.7

5

Chickens:
  • Prevention of chronic respiratory disease (CRD) and air sacculitis: 12.5 mg tiamulin hydrogen fumarate / kg bodyweight
  • Treatment of chronic respiratory disease (CRD) and air sacculitis: 25 mg tiamulin hydrogen fumarate / kg bodyweight
Turkeys:
  • Prevention of infectious sinusitis and air sacculitis: 12.5 mg tiamulin hydrogen fumarate / kg bodyweight
  • Treatment of infectious sinusitis and air sacculitis: 25 mg tiamulin hydrogen fumarate / kg bodyweight

Indications

Tiamulin (concentration in water in %)

Product
(in ml)

Water
(in liters)

Treatment
(in days)

Prevention CRD / air sacculitis / infectious sinusitis

0.0125

1

1

3 days (1st week of life); 1-2 days every 3-4 weeks

Treatment CRD / air sacculitis / infectious sinusitis

0.025

2

1

3 – 5

Withdrawal Periods

Withdrawal periods according to national registrations.

Special Precautions and Warnings

Do not administer ionophore anticoccidials (salinomycin, monensin, narasin) to pigs and poultry receiving therapeutic doses of DENAGARD. Pigs and poultry should not receive products containing ionophores during or for at least seven days before or after treatment with DENAGARD.

Formulations and Packages

DENAGARD 12.5% Solution
  • 1 litre dispensing packs




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PAGE VERSION: INTERNATIONAL

Product information on this website is for Non-U.S. residents only and is provided by Novartis Animal Health Inc. for general purposes only. Many veterinary products listed are available upon prescription only, and not all such products may be available in all countries. The product information is not intended to provide complete medical information. SHOULD YOUR ANIMAL HAVE A MEDICAL CONDITION, PROMPTLY SEE YOUR OWN VETERINARIAN. WE DO NOT OFFER PERSONALIZED MEDICAL DIAGNOSIS OR ANIMAL-SPECIFIC TREATMENT ADVICE. You should always obtain complete medical information about your veterinary product prescription (including their beneficial medical uses and possible adverse effects) by discussing the appropriate use of any veterinary product directly with the prescribing veterinarian.

Veterinary professionals may obtain complete medical information from the product's information leaflet. Information on these products may vary by country. Animal owners and veterinarians should check with local medical resources and regulatory authorities for information appropriate to their country. In addition, current regulations in many countries limit (or even prohibit in some instances) the ability of Novartis Animal Health Inc. to provide information and/or to respond directly to questions regarding its prescription products. Novartis Animal Health Inc., however, will respond to inquiries from and provide information to your qualified health care professional in accordance with local regulations.
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