THE COMPARATIVE EFFICACY OF ANTIMICROBIALS FOR THE PREVENTION AND TREATMENT OF ENZOOTIC PNEUMONIA AND SOME OF THEIR PHARMACOKINETIC/PHARMACODYNAMIC RELATIONSHIPS
D.G.S. Burch

Abstract
Enzootic pneumonia is a widespread respiratory disease of swine, caused by Mycoplasma hyopneumoniae. It has been a difficult disease to control with the use of medication. The purpose of this paper is to examine the activity of various antimicrobials, both in vitro and in vivo, and to attempt to correlate their pharmacokinetics in both blood and lung with their activity and efficacy. From this analysis, some basic pharmacodynamic relationships, applicable to both bactericidal and bacteriostatic antimicrobials, can be established.

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