COLON CONTENTS CONCENTRATION AND AREA UNDER THE CURVE/MINIMUM INHIBITORY CONCENTRATION RELATIONSHIPS FOR VALNEMULIN - PREVENTION, TREATMENT AND ELIMINATION OF SWINE DYSENTERY
D.G.S. Burch, P. Ripley and M. Burrows

Abstract
(Members' Paper) Following the introduction of the European Guideline EMEA/CVMP/627/01-FINAL - ('Guidelines for the demonstration of efficacy for veterinary medicinal products containing antimicrobial substances'), using pharmacokinetic/pharmacodynamic (PK/PD) methods of analysis are recommended for evaluating medicines. The guidelines were set with bactericidal antimicrobial models in mind, with bacterial elimination as an endpoint to try to reduce resistance development; but many products used in pig medicine are primarily bacteriostatic. Valnemulin for the prevention and treatment of swine dysentery was applied to a large intestine infection PK/PD model. This demonstrated that the minimum bactericidal concentration (MBC) was more relevant than minimum inhibitory concentration (MIC). Prevention of swine dysentery is a valid and definable claim with a good antibacterial endpoint. Treatment is more complex due to the nature of the disease and the mode of action of the antibiotic. Significantly higher concentrations of valnemulin (times 10) are required to eliminate infection and there is a higher risk of incomplete treatment and potential resistance development. Fortunately, Brachyspira hyodysenteriae develops resistance slowly to valnemulin.

Add to Basket