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Pig Journal Volume: 55
Publication date: May 2005

Reviews

PATHOPHYSIOLOGY OF THE PIG LUNG
S.H. Done

Abstract
In this paper, a discussion of the environment, the design of the respiratory tract and the potential and actual threats from the microbiological agents are reviewed. The defensive systems are very extensive and are defeated either by agents disturbing mucociliary clearance (Ammonia, swine influenza) or the alveolar macrophage PRRS and PCV2. Epitheliotropic agents such as Bordetellae, Pasteurellae and swine influenza and toxin producers such as Actinobacillus pleuropneumoniae are particularly disturbing. As yet, the complex pathogenetic mechanisms of Pasteurella multocida and Haemophilus suis are not well understood. The interactions of PRRS in disrupting both cellular and humoral immunity are increasingly appreciated with time and more research but the pathogenesis of PCV infections and its interaction with other pathogens and the host is still a mystery.

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