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Pig Journal Volume: 55
Publication date: May 2005

Reviews

THERAPY OF SWINE RESPIRATORY DISEASES: RELEVANCE OF PHARMACOLOGICAL CRITERIA IN THE CHOICE OF DRUGS
R. Odore, P. Badino, R. Barbero and G. Re

Abstract
Since respiratory diseases are one of the main causes of economic losses in the swine industry, the knowledge of the mechanism of action and of the pharmacokinetic characteristics of drugs commonly used for this purpose is a crucial point to assess therapeutic protocols that may ensure a favourable cost/benefit ratio. Antibiotics and anti-inflammatory agents are essential tools for the control of swine respiratory diseases. Besides the fact that some of these molecules have been known for a long time, therapeutic protocols are often based on clinical and/or microbiological criteria, while the importance of considering the pharmacological characteristics of such drugs is sometimes underestimated. Moreover, it should be emphasized that the pharmacological treatments may be successful only if associated with a good management of the herd and with a high degree of environmental hygiene. The review describes the main pharmacological characteristics of chaemo-antibiotics and anti-inflammatory drugs, emphasizing the importance of integrating pharmacokinetic and pharmacodynamic parameters in order to obtain

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