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Pig Journal Volume: 56
Publication date: November 2005

Proceedings Section

POST-WEANING MULTISYSTEMIC WASTING SYNDROME (PMWS) IN FARMS: DEFINING DISEASE AND THE ROLE OF PORCINE CIRCOVIRUS 2 (PCV2)
M. Turner, C. Schnier, K. Woodbine, L. Green, G. Medley and J. Slevin

Abstract
The cause of PMWS is as yet undetermined. There has been great controversy over the role of PCV2 in the disease. Current case definitions for the disease vary, but all include the presence of PCV2 antigen or nucleic acid. In a cross-sectional study of 116 farms, there was little difference in the PCV2 serological profiles of PMWS positive, negative and recovered farms. However, PCV2 antigen levels were more raised in sick pigs on all farms. There were also high levels on farms where the farmers had not reported PMWS and some positive farms where no antigen was detected. Antigen levels were correlated with current mortality with PMWS on the farms. Porcine circovirus 2 was not included in the proposed case definition due to the uncertainty of its role in the disease.
There were 28 significant differences between the post-mortem examination (PME) of sick and healthy pigs, ignoring farm of origin. These differences were mainly enteric and respiratory. There were three significant differences between the histology results from sick and healthy pigs. These differences were significant in the ileoceacocolic lymph node. A case definition has been proposed using these significantly different signs.

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