THE USE OF PRACETAM (PARACETAMOL) PREMIX IN POST-WEANING MULTISYSTEMIC WASTING SYNDROME (PMWS) AND POST-WEANING DIETS
L. Glattleider and N. Capdevielle

Abstract
Controlled clinical trials were performed to evaluate the effect of PRACETAM in either PMWS or in a post-weaning diet.
The efficacy of PRACETAM was demonstrated by a controlled clinical trial under blind conditions in a pig herd chronically infected with PMWS. The therapeutic dose in the treated group was 30 milligrams of Paracetamol per kilograms body weight (1000 milligrams per kilogram of feed) for ten consecutive days and no concomitant antibiotic treatment was used. During the first period of the trial (between day 0 and day fourteen), only a small number of pigs died or lost weight. The difference between the treated and control group was not significant. During the second period of the trial, a statistically significant difference in the number of dead or wasting pigs was observed between the treated and control group and treatment with PRACETAM was concluded to have helped in reducing the mortality rate and the number of wasting piglets.
A controlled trial was carried out to evaluate the effect of PRACETAM on growth rate during the post-weaning period. Three hundred and fifty-one piglets were involved in this study, from the day of weaning (day zero) to the end of the post- weaning period (day 35), randomly divided into a control and a treated group and reared under different conditions. Under favourable conditions (5 piglets per box and completely slatted floor), a significant effect of PRACETAM was observed on growth performance with daily weight gain 55g higher than in the control group). Under unfavourable conditions (10 piglets per box, partially slatted floor and stimulation of the immune system by vaccination against Mycoplasma), an even greater effect of PRACETAM was seen throughout the growth period, despite the immune stimulation.

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