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Pig Journal Volume: 59
Publication date: July 2007

Proceedings Section

POST-WEANING E.COLI DIARRHOEA
R.M. Friendship and M.R. Amezcua

Abstract
Post-weaning diarrhoea in pigs is a complex disease with multiple contributory factors. In the late 1990s, an outbreak of disease occurred in Ontario characterized by sudden death and severe watery diarrhoea in newly weaned pigs. An investigation was undertaken to determine whether the disease was caused by a change in management and/or nutrition or whether<i> E. coli</i> had become more virulent. In addition, a series of trials, both clinical field studies and controlled challenge studies, were undertaken to determine the efficacy of various control measures. In a case-control study of 50 farms, it was determined that management factors did not appear to be associated with an increased risk of disease. The most common <i>E. coli</i> isolated from cases of diarrhoea O149 F4 (STa, STb, LT) was shown to be different from the predominant strains isolated from cases a decade earlier, suggesting that the disease was in part due to a more virulent pathogen. Novel approaches to control of the disease including vaccination, egg-yolk antibody products, probiotics, essential oils and bacteriophages were investigated. Certain of these intervention strategies showed promise in the laboratory and in controlled studies, but their effectiveness under the field conditions remains in doubt.

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