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Pig Journal Volume: 51
Publication date: June 2003

Proceedings Section

ON-FARM POST-WEANING MULTISYSTEMIC WASTING SYNDROME (PMWS)/PORCINE DERMATITIS AND NEPHROPATHY SYNDROME (PDNS) STUDY: AIMS AND OBJECTIVES
D.P. King, S.S. Grierson, M. Banks, A.C.J. Gresham, M. Bailey, K. Haverson, C. Sargent, G.J. Wellenburg, D. Tucker, M. Donadeu and M. Mellencamp

Abstract
Porcine circovirus-2 (PCV-2) has been implicated as the causative agent of Post-weaning multisystemic wasting syndrome (PMWS) and has been closely associated with Porcine dermatitis and nephropathy syndrome (PDNS). However, it is apparent from a number of experimental studies, that when inoculated alone, PCV-2 does not consistently reproduce disease. This observation has driven speculation regarding the likely contribution of additional factors that may have impacted upon the increased expression of these syndromes in UK pigs in the past three years. In order to address this question, the immunological and transcriptional events occurring in individual piglets prior to the clinical presentation of PMWS and PDNS will be monitored and compared with unaffected litter-mates. This will allow key biochemical pathways that modulate the expression of these syndromes to be identified. This knowledge should facilitate the development and targeting of therapeutics, vaccines and diagnostic tests for these important emerging pig diseases.

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