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Pig Journal Volume: 49
Publication date: June 2002

Refereed Section

EVALUATION OF THE FIELD EFFICACY AND SAFETY OF A MYCOPLASMA HYOPNEUMONIAE VACCINE IN FINISHING PIGS
by D. Llopart, J. Casal, J. Clota, I. Navarra, R. March, P. Riera and C. Artigas

Abstract
The safety and efficacy of an inactivated vaccine against M. hyopneumoniae (MYPRAVAC SUIS - Laboratorios Hipra) was evaluated under field conditions on 706 piglets at seven to ten days of age from three different commercial Large White x Landrace breeding units. Two treatment groups were established within each unit: Group One was vaccinated then revaccinated 21 days later. Group Two was treated with a placebo following the same schedule as Group 0ne. At eight weeks of age, the piglets were transferred to a growing-finishing building with a 700-pig capacity. Mortality rates were recorded and cause of death determined by microbiological analysis. Body Weight, Carcass Weight, Daily Weight Gain, Food Consumption, Food Conversion Rate and days of occupation were evaluated at the end of the trial. Pulmonary lesions caused by M. hyopneumoniae were scored at slaughter.
???? Seroconversion was evident in 100 per cent and 94.3 per cent of the vaccinated and control samples respectively. Histopathology and Direct Immunofluorescence confirmed that both groups had been in contact with M. hyopneumoniae. The results showed that the vaccine provoked neither fever (p 0.05), nor local reaction although two piglets did vomit 30 min. after vaccination. Significant differences were found when evaluating the productive parameters between groups. Group 0ne presented a significant reduction (p<0.00001) of the pulmonary lesions attributed to M. hyopneumoniae compared with Group Two.

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