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Vaccination
Management
Disease Information
A PMWS update (Jake Waddilove)
ABOUT PMWS & PDNS
National Pork Board PMWS Fact Sheet
About PDNS (Jake Waddilive)
CEI Emerging Disease Notices: PMWS / PDNS
Conference and meetings archive
Case Histories
Yorkshire Farm, UK - Mike Muirhead - Final Update, June 2002
Mike Muirhead's case history of a Yorkshire farm with PMWS and PDNS.
 
East Anglia Farm, UK - Philip Richardson
This paper charts the course and effects of the disease on a single herd as well as highlighting the economic impact.
Photographs
Clinical signs
Photos of the clinical signs that are seen generally in pigs with PMWS and PDNS. Includes skin lesions, enlarged lymph glands, wasting and dead pigs.
 
Post mortem (1)
Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS. Includes interstitial pneumonia, secondary bacterial infection, enlarged lymph nodes, oedema and intra cytoplasmic inclusions
 
Post mortem (2)
More Photos of the signs that are seen in post-mortem samples of pigs with PMWS and PDNS.


PMWS Research Archives

Published Wednesday, September 01, 2004: Journal of Comparative Pathology - August-October 2004 Volume 131, Issues 2-3, Pages 121-126
Expression of Monocyte Chemoattractant Protein-1 and Macrophage Inflammatory Protein-1 in Porcine Circovirus 2-induced Granulomatous Inflammation
J. Kim and C. Chae - Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, San 56-1, Shillim-Dong, Kwanak-Gu 141-742, Seoul, South Korea
The expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1) in granulomatous inflammation of lymph nodes was determined in 1-day-old piglets inoculated intranasally with porcine circovirus 2 (PCV2). The methods used were reverse transcription-polymerase chain reaction (RT-PCR), granulomatous lesion scoring, and in-situ hybridization. Maximum MCP-1 expression and MIP-1 expression were observed at 17 and 21 days post-inoculation (dpi), respectively. Granulomatous lesions of maximum severity were observed somewhat later (28 dpi). A close cell to cell relation between PCV2 and the two cytokines in serial sections from lymph nodes suggested that their induction was a direct response to PCV2. The results provide evidence of the ability of MCP-1 and MIP-1 to induce granulomatous inflammation in vivo.

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